Reaction Details  Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50139095
Substrate
n/a
Meas. Tech.
ChEBML_144141
IC50
>10000±n/a nM
Citation
 Galiano, S; Erviti, O; Pérez, S; Moreno, A; Juanenea, L; Aldana, I; Monge, A Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists. Bioorg Med Chem Lett 14:597-9 (2004) [PubMed]
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50139095
Synonyms:
4-Chloro-N-{4-[N'-(thiophene-2-carbonyl)-hydrazinocarbonyl]-cyclohexylmethyl}-benzenesulfonamide | CHEMBL439638
Type:
Small organic molecule
Emp. Form.:
C19H22ClN3O4S2
Mol. Mass.:
455.979
SMILES:
Clc1ccc(cc1)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)C(=O)NNC(=O)c1cccs1 |wU:12.12,wD:15.19,(-1.89,-5.71,;-.54,-4.98,;.78,-5.79,;2.13,-5.07,;2.18,-3.54,;.87,-2.71,;-.48,-3.44,;3.53,-2.82,;2.77,-1.31,;4.81,-1.61,;4.84,-3.64,;6.2,-2.91,;7.51,-3.73,;8.87,-3.01,;10.17,-3.81,;10.12,-5.35,;8.77,-6.09,;7.45,-5.27,;11.43,-6.16,;11.38,-7.7,;12.78,-5.44,;14.09,-6.25,;15.45,-5.53,;15.49,-3.99,;16.75,-6.33,;16.87,-7.87,;18.36,-8.23,;19.15,-6.93,;18.17,-5.74,)|
Structure:
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