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Target
Neuropeptide Y receptor type 1
Ligand
BDBM50139100
Substrate
n/a
Meas. Tech.
ChEBML_144141
IC50
>10000±n/a nM
Citation
 Galiano, S; Erviti, O; Pérez, S; Moreno, A; Juanenea, L; Aldana, I; Monge, A Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists. Bioorg Med Chem Lett 14:597-9 (2004) [PubMed]
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50139100
Synonyms:
4-Bromo-N-{4-[N'-(thiophene-2-carbonyl)-hydrazinocarbonyl]-cyclohexylmethyl}-benzenesulfonamide | CHEMBL152016
Type:
Small organic molecule
Emp. Form.:
C19H22BrN3O4S2
Mol. Mass.:
500.43
SMILES:
Brc1ccc(cc1)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)C(=O)NNC(=O)c1cccs1 |wU:12.12,wD:15.19,(-1.88,-5.71,;-.53,-4.98,;.79,-5.79,;2.15,-5.07,;2.19,-3.54,;.89,-2.71,;-.48,-3.44,;3.54,-2.82,;2.78,-1.31,;4.83,-1.61,;4.85,-3.64,;6.21,-2.91,;7.52,-3.73,;8.87,-3.01,;10.18,-3.81,;10.13,-5.35,;8.78,-6.09,;7.46,-5.27,;11.43,-6.16,;11.39,-7.7,;12.79,-5.44,;14.09,-6.25,;15.45,-5.53,;15.49,-3.99,;16.77,-6.33,;16.87,-7.87,;18.36,-8.23,;19.18,-6.93,;18.19,-5.74,)|
Structure:
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