Reaction Details  Report a problem with these data
Target
Neuropeptide Y receptor type 1
Ligand
BDBM50139099
Substrate
n/a
Meas. Tech.
ChEBML_144141
IC50
>10000±n/a nM
Citation
 Galiano, S; Erviti, O; Pérez, S; Moreno, A; Juanenea, L; Aldana, I; Monge, A Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists. Bioorg Med Chem Lett 14:597-9 (2004) [PubMed]
Target
Name:
Neuropeptide Y receptor type 1
Synonyms:
NPY-Y1 | NPY1-R | NPY1R | NPY1R_HUMAN | NPYR | NPYY1 | neuropeptide Y receptor Y1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44399.07
Organism:
Homo sapiens (Human)
Description:
NPY-Y1 NPY1R HUMAN::P25929
Residue:
384
Sequence:
MNSTLFSQVENHSVHSNFSEKNAQLLAFENDDCHLPLAMIFTLALAYGAVIILGVSGNLALIIIILKQKEMRNVTNILIVNLSFSDLLVAIMCLPFTFVYTLMDHWVFGEAMCKLNPFVQCVSITVSIFSLVLIAVERHQLIINPRGWRPNNRHAYVGIAVIWVLAVASSLPFLIYQVMTDEPFQNVTLDAYKDKYVCFDQFPSDSHRLSYTTLLLVLQYFGPLCFIFICYFKIYIRLKRRNNMMDKMRDNKYRSSETKRINIMLLSIVVAFAVCWLPLTIFNTVFDWNHQIIATCNHNLLFLLCHLTAMISTCVNPIFYGFLNKNFQRDLQFFFNFCDFRSRDDDYETIAMSTMHTDVSKTSLKQASPVAFKKINNNDDNEKI
  
Inhibitor
Name:
BDBM50139099
Synonyms:
CHEMBL153522 | N-{4-[N'-(Benzo[b]thiophene-2-carbonyl)-hydrazinocarbonyl]-cyclohexylmethyl}-4-bromo-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H24BrN3O4S2
Mol. Mass.:
550.488
SMILES:
Brc1ccc(cc1)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)C(=O)NNC(=O)c1cc2ccccc2s1 |wU:12.12,wD:15.19,(-3.85,-.38,;-2.5,.35,;-1.18,-.47,;.17,.26,;.22,1.79,;-1.09,2.61,;-2.44,1.89,;1.57,2.51,;.82,4.03,;2.85,3.72,;2.88,1.69,;4.25,2.42,;5.55,1.6,;6.91,2.32,;8.21,1.52,;8.16,-.02,;6.81,-.75,;5.49,.06,;9.47,-.84,;9.42,-2.36,;10.82,-.1,;12.14,-.92,;13.49,-.19,;13.54,1.35,;14.8,-1,;14.91,-2.53,;16.41,-2.9,;17.13,-4.25,;18.68,-4.3,;19.49,-2.99,;18.75,-1.63,;17.21,-1.59,;16.22,-.4,)|
Structure:
Search PDB for entries with ligand similarity: