Reaction Details  Report a problem with these data
Target
Neuropeptide Y receptor type 5
Ligand
BDBM50139105
Substrate
n/a
Meas. Tech.
ChEBML_144156
IC50
43±n/a nM
Citation
 Galiano, S; Erviti, O; Pérez, S; Moreno, A; Juanenea, L; Aldana, I; Monge, A Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists. Bioorg Med Chem Lett 14:597-9 (2004) [PubMed]
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50139105
Synonyms:
CHEMBL158344 | N-{4-[N'-(Benzo[b]thiophene-2-carbonyl)-hydrazinocarbonyl]-cyclohexylmethyl}-4-methyl-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C24H27N3O4S2
Mol. Mass.:
485.619
SMILES:
Cc1ccc(cc1)S(=O)(=O)NC[C@H]1CC[C@@H](CC1)C(=O)NNC(=O)c1cc2ccccc2s1 |wU:12.12,wD:15.19,(-2.29,-.98,;-.93,-.24,;.38,-1.06,;1.73,-.33,;1.78,1.19,;.47,2.02,;-.88,1.3,;3.13,1.91,;2.38,3.42,;4.42,3.12,;4.44,1.1,;5.81,1.82,;7.11,1,;8.47,1.73,;9.77,.92,;9.72,-.61,;8.37,-1.35,;7.05,-.54,;11.03,-1.43,;10.98,-2.97,;12.38,-.71,;13.7,-1.52,;15.05,-.79,;15.1,.75,;16.36,-1.59,;16.47,-3.13,;17.96,-3.5,;18.69,-4.86,;20.24,-4.91,;21.04,-3.58,;20.31,-2.22,;18.77,-2.19,;17.78,-1.01,)|
Structure:
Search PDB for entries with ligand similarity: