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Target
Neuropeptide Y receptor type 5
Ligand
BDBM50139108
Substrate
n/a
Meas. Tech.
ChEBML_144156
IC50
175±n/a nM
Citation
 Galiano, S; Erviti, O; Pérez, S; Moreno, A; Juanenea, L; Aldana, I; Monge, A Synthesis of new thiophene and benzo[b]thiophene hydrazide derivatives as human NPY Y(5) antagonists. Bioorg Med Chem Lett 14:597-9 (2004) [PubMed]
Target
Name:
Neuropeptide Y receptor type 5
Synonyms:
NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor
Type:
Enzyme
Mol. Mass.:
50746.64
Organism:
Homo sapiens (Human)
Description:
Q15761
Residue:
445
Sequence:
MDLELDEYYNKTLATENNTAATRNSDFPVWDDYKSSVDDLQYFLIGLYTFVSLLGFMGNLLILMALMKKRNQKTTVNFLIGNLAFSDILVVLFCSPFTLTSVLLDQWMFGKVMCHIMPFLQCVSVLVSTLILISIAIVRYHMIKHPISNNLTANHGYFLIATVWTLGFAICSPLPVFHSLVELQETFGSALLSSRYLCVESWPSDSYRIAFTISLLLVQYILPLVCLTVSHTSVCRSISCGLSNKENRLEENEMINLTLHPSKKSGPQVKLSGSHKWSYSFIKKHRRRYSKKTACVLPAPERPSQENHSRILPENFGSVRSQLSSSSKFIPGVPTCFEIKPEENSDVHELRVKRSVTRIKKRSRSVFYRLTILILVFAVSWMPLHLFHVVTDFNDNLISNRHFKLVYCICHLLGMMSCCLNPILYGFLNNGIKADLVSLIHCLHM
  
Inhibitor
Name:
BDBM50139108
Synonyms:
CHEMBL154412 | N-{4-[N'-(Benzo[b]thiophene-2-carbonyl)-hydrazinocarbonyl]-cyclohexylmethyl}-benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C23H25N3O4S2
Mol. Mass.:
471.592
SMILES:
O=C(NNC(=O)c1cc2ccccc2s1)[C@H]1CC[C@H](CNS(=O)(=O)c2ccccc2)CC1 |wU:18.20,wD:15.16,(14.14,-4.99,;14.19,-3.46,;15.54,-2.73,;16.84,-3.53,;18.2,-2.81,;18.24,-1.27,;19.5,-3.62,;19.62,-5.15,;21.11,-5.51,;21.85,-6.88,;23.4,-6.93,;24.21,-5.6,;23.47,-4.25,;21.93,-4.21,;20.94,-3.04,;12.88,-2.64,;12.93,-1.1,;11.62,-.29,;10.27,-1.01,;8.96,-.19,;7.6,-.92,;6.3,-.1,;5.53,1.4,;7.58,1.11,;4.94,-.82,;4.9,-2.36,;3.54,-3.09,;2.22,-2.27,;2.27,-.73,;3.64,-.01,;10.21,-2.55,;11.53,-3.37,)|
Structure:
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