Reaction Details  Report a problem with these data
Target
5-hydroxytryptamine receptor 1A
Ligand
BDBM50139351
Substrate
n/a
Meas. Tech.
ChEBML_912
Ki
8.7±n/a nM
Citation
 Thomson, CG; Beer, MS; Curtis, NR; Diggle, HJ; Handford, E; Kulagowski, JJ Thiazoles and thiopyridines: novel series of high affinity h5HT(7) ligands. Bioorg Med Chem Lett 14:677-80 (2004) [PubMed]
Target
Name:
5-hydroxytryptamine receptor 1A
Synonyms:
5-HT-1A | 5-HT1A | 5-hydroxytryptamine receptor 1A (5-HT-1A) | 5HT1A_HUMAN | ADRB2RL1 | ADRBRL1 | Dopamine D2 receptor and serotonin 1a receptor | G-21 | HTR1A | Serotonin receptor 1A
Type:
n/a
Mol. Mass.:
46122.49
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
422
Sequence:
MDVLSPGQGNNTTSPPAPFETGGNTTGISDVTVSYQVITSLLLGTLIFCAVLGNACVVAAIALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCCTSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPEDRSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKTGADTRHGASPAPQPKKSVNGESGSRNWRLGVESKAGGALCANGAVRQGDDGAALEVIEVHRVGNSKEHLPLPSEAGPTPCAPASFERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLPFFIVALVLPFCESSCHMPTLLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFCRQ
  
Inhibitor
Name:
BDBM50139351
Synonyms:
2-(6-cyclohexylpyridin-2-ylthio)-N,N-dimethylethanamine | CHEMBL158402 | [2-(6-Cyclohexyl-pyridin-2-ylsulfanyl)-ethyl]-dimethyl-amine
Type:
Small organic molecule
Emp. Form.:
C15H24N2S
Mol. Mass.:
264.429
SMILES:
CN(C)CCSc1cccc(n1)C1CCCCC1
Structure:
Search PDB for entries with ligand similarity: