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Target
Histamine H3 receptor
Ligand
BDBM50139392
Substrate
n/a
Meas. Tech.
ChEMBL_87053 (CHEMBL697326)
Ki
30±n/a nM
Citation
 Cowart, M; Pratt, JK; Stewart, AO; Bennani, YL; Esbenshade, TA; Hancock, AA A new class of potent non-imidazole H(3) antagonists: 2-aminoethylbenzofurans. Bioorg Med Chem Lett 14:689-93 (2004) [PubMed]
Target
Name:
Histamine H3 receptor
Synonyms:
HH3R | HRH3_RAT | Hrh3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
48607.98
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
445
Sequence:
MERAPPDGLMNASGTLAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFVADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCASSVFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMALVWVLAFLLYGPAILSWEYLSGGSSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGGREAGPEPPPDAQPSPPPAPPSCWGCWPKGHGEAMPLHRYGVGEAGPGVEAGEAALGGGSGGGAAASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSITQRFRLSRDKKVAKSLAIIVSIFGLCWAPYTLLMIIRAACHGRCIPDYWYETSFWLLWANSAVNPVLYPLCHYSFRRAFTKLLCPQKLKVQPHGSLEQCWK
  
Inhibitor
Name:
BDBM50139392
Synonyms:
CHEMBL422360 | Morpholin-4-yl-{6-[2-(2-pyrrolidin-1-yl-ethyl)-benzofuran-5-yl]-pyridin-3-yl}-methanone
Type:
Small organic molecule
Emp. Form.:
C24H27N3O3
Mol. Mass.:
405.4895
SMILES:
O=C(N1CCOCC1)c1ccc(nc1)-c1ccc2oc(CCN3CCCC3)cc2c1
Structure:
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