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Target
Cholinesterase
Ligand
BDBM50574186
Substrate
n/a
Meas. Tech.
ChEMBL_2121956 (CHEMBL4831103)
IC50
269±n/a nM
Citation
 Wichur, T; Gody?, J; Góral, I; Latacz, G; Bucki, A; Siwek, A; G?uch-Lutwin, M; Mordyl, B; ?niecikowska, J; Walczak, M; Knez, D; Juki?, M; Sa?at, K; Gobec, S; Ko?aczkowski, M; Malawska, B; Brazzolotto, X; Wi?ckowska, A Development and crystallography-aided SAR studies of multifunctional BuChE inhibitors and 5-HT Eur J Med Chem 225:0 (2021) [PubMed]  Article
Target
Name:
Cholinesterase
Synonyms:
BCHE | Butyrylcholinesterase (BuChE) | CHLE_HORSE | Cholinesterase
Type:
Enzyme
Mol. Mass.:
65643.35
Organism:
Equus caballus (Horse)
Description:
P81908
Residue:
574
Sequence:
EEDIIITTKNGKVRGMNLPVLGGTVTAFLGIPYAQPPLGRLRFKKPQSLTKWSNIWNATKYANSCYQNTDQSFPGFLGSEMWNPNTELSEDCLYLNVWIPAPKPKNATVMIWIYGGGFQTGTSSLPVYDGKFLARVERVIVVSMNYRVGALGFLALSENPEAPGNMGLFDQQLALQWVQKNIAAFGGNPRSVTLFGESAGAASVSLHLLSPRSQPLFTRAILQSGSSNAPWAVTSLYEARNRTLTLAKRMGCSRDNETEMIKCLRDKDPQEILLNEVFVVPYDTLLSVNFGPTVDGDFLTDMPDTLLQLGQFKRTQILVGVNKDEGTAFLVYGAPGFSKDNNSIITRKEFQEGLKIFFPRVSEFGRESILFHYMDWLDDQRAENYREALDDVVGDYNIICPALEFTRKFSELGNDAFFYYFEHRSTKLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEILSRSIMKRWANFAKYGNPNGTQNNSTRWPVFKSTEQKYLTLNTESPKVYTKLRAQQCRFWTLFFPKVLELTGNIDEAEREWKAGFHRWNNYMMDWKNQFNDYTSKKESCSDF
  
Inhibitor
Name:
BDBM50574186
Synonyms:
CHEMBL4853545
Type:
Small organic molecule
Emp. Form.:
C22H26N2O3S
Mol. Mass.:
398.518
SMILES:
O=S(=O)(c1ccccc1)n1ccc2c(OCCNCC3CCCC3)cccc12
Structure:
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