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Target
Kallikrein-6
Ligand
BDBM50574432
Substrate
n/a
Meas. Tech.
ChEMBL_2122490 (CHEMBL4831723)
Ki
1500±n/a nM
Citation
 Aït Amiri, S; Deboux, C; Soualmia, F; Chaaya, N; Louet, M; Duplus, E; Betuing, S; Nait Oumesmar, B; Masurier, N; El Amri, C Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation. J Med Chem 64:5667-5688 (2021) [PubMed]  Article
Target
Name:
Kallikrein-6
Synonyms:
KLK6 | KLK6_HUMAN | Kallikrein 6 | PRSS18 | PRSS9
Type:
PROTEIN
Mol. Mass.:
26861.50
Organism:
Homo sapiens (Human)
Description:
ChEMBL_826901
Residue:
244
Sequence:
MKKLMVVLSLIAAAWAEEQNKLVHGGPCDKTSHPYQAALYTSGHLLCGGVLIHPLWVLTAAHCKKPNLQVFLGKHNLRQRESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLERDCSANTTSCHILGWGKTADGDFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVCGDHLRGLVSWGNIPCGSKEKPGVYTNVCRYTNWIQKTIQAK
  
Inhibitor
Name:
BDBM50574432
Synonyms:
CHEMBL4863108
Type:
Small organic molecule
Emp. Form.:
C17H21ClN2O2
Mol. Mass.:
320.814
SMILES:
Cl.CC(C)c1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1
Structure:
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