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Target
Kallikrein-1
Ligand
BDBM50574431
Substrate
n/a
Meas. Tech.
ChEMBL_2122493 (CHEMBL4831726)
IC50
26300±n/a nM
Citation
 Aït Amiri, S; Deboux, C; Soualmia, F; Chaaya, N; Louet, M; Duplus, E; Betuing, S; Nait Oumesmar, B; Masurier, N; El Amri, C Identification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation. J Med Chem 64:5667-5688 (2021) [PubMed]  Article
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM50574431
Synonyms:
CHEMBL4847066
Type:
Small organic molecule
Emp. Form.:
C15H17ClN2O2
Mol. Mass.:
292.761
SMILES:
Cl.Cc1ccc(C(=O)Nc2ccc(CN)cc2)c(O)c1
Structure:
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