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Target
Galectin-8
Ligand
BDBM50574681
Substrate
n/a
Meas. Tech.
ChEMBL_2123003 (CHEMBL4832236)
Kd
1200000±n/a nM
Citation
 Hassan, M; van Klaveren, S; Håkansson, M; Diehl, C; Kova?i?, R; Baussière, F; Sundin, AP; Dernov?ek, J; Walse, B; Zetterberg, F; Leffler, H; Anderluh, M; Toma?i?, T; Jakopin, ?; Nilsson, UJ Benzimidazole-galactosides bind selectively to the Galectin-8 N-Terminal domain: Structure-based design and optimisation. Eur J Med Chem 223:0 (2021) [PubMed]  Article
Target
Name:
Galectin-8
Synonyms:
Gal-8 | LEG8_HUMAN | LGALS8 | PCTA-1 | Po66 carbohydrate-binding protein | Po66-CBP | Prostate carcinoma tumor antigen 1
Type:
PROTEIN
Mol. Mass.:
35814.23
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1454625
Residue:
317
Sequence:
MMLSLNNLQNIIYNPVIPFVGTIPDQLDPGTLIVIRGHVPSDADRFQVDLQNGSSMKPRADVAFHFNPRFKRAGCIVCNTLINEKWGREEITYDTPFKREKSFEIVIMVLKDKFQVAVNGKHTLLYGHRIGPEKIDTLGIYGKVNIHSIGFSFSSDLQSTQASSLELTEISRENVPKSGTPQLRLPFAARLNTPMGPGRTVVVKGEVNANAKSFNVDLLAGKSKDIALHLNPRLNIKAFVRNSFLQESWGEEERNITSFPFSPGMYFEMIIYCDVREFKVAVNGVHSLEYKHRFKELSSIDTLEINGDIHLLEVRSW
  
Inhibitor
Name:
BDBM50574681
Synonyms:
CHEMBL4865708
Type:
Small organic molecule
Emp. Form.:
C24H27N3O7S
Mol. Mass.:
501.552
SMILES:
COC(=O)c1cccc(c1)-n1cc(CO[C@H]2[C@@H](O)[C@@H](CO)O[C@@H](Sc3ccc(C)cc3)[C@@H]2O)nn1 |r|
Structure:
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