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Target
Lysine-specific demethylase 4D
Ligand
BDBM50498665
Substrate
n/a
Meas. Tech.
ChEMBL_2123126 (CHEMBL4832359)
IC50
290±n/a nM
Citation
 Fang, Z; Liu, Y; Zhang, R; Chen, Q; Wang, T; Yang, W; Fan, Y; Yu, C; Xiang, R; Yang, S Discovery of a potent and selective inhibitor of histone lysine demethylase KDM4D. Eur J Med Chem 223:0 (2021) [PubMed]  Article
Target
Name:
Lysine-specific demethylase 4D
Synonyms:
JHDM3D | JHDM3D | JMJD2D | JmjC domain-containing histone demethylation protein 3D | Jumonji domain-containing protein 2D | KDM4D | KDM4D_HUMAN | Lysine-specific demethylase 4D
Type:
PROTEIN
Mol. Mass.:
58627.79
Organism:
Homo sapiens (Human)
Description:
ChEMBL_102441
Residue:
523
Sequence:
METMKSKANCAQNPNCNIMIFHPTKEEFNDFDKYIAYMESQGAHRAGLAKIIPPKEWKARETYDNISEILIATPLQQVASGRAGVFTQYHKKKKAMTVGEYRHLANSKKYQTPPHQNFEDLERKYWKNRIYNSPIYGADISGSLFDENTKQWNLGHLGTIQDLLEKECGVVIEGVNTPYLYFGMWKTTFAWHTEDMDLYSINYLHLGEPKTWYVVPPEHGQRLERLARELFPGSSRGCGAFLRHKVALISPTVLKENGIPFNRITQEAGEFMVTFPYGYHAGFNHGFNCAEAINFATPRWIDYGKMASQCSCGEARVTFSMDAFVRILQPERYDLWKRGQDRAVVDHMEPRVPASQELSTQKEVQLPRRAALGLRQLPSHWARHSPWPMAARSGTRCHTLVCSSLPRRSAVSGTATQPRAAAVHSSKKPSSTPSSTPGPSAQIIHPSNGRRGRGRPPQKLRAQELTLQTPAKRPLLAGTTCTASGPEPEPLPEDGALMDKPVPLSPGLQHPVKASGCSWAPVP
  
Inhibitor
Name:
BDBM50498665
Synonyms:
CHEMBL1982368
Type:
Small organic molecule
Emp. Form.:
C17H13ClN4
Mol. Mass.:
308.765
SMILES:
Clc1ccc(N\N=C(/c2ccccc2)c2ccccn2)nc1
Structure:
Search PDB for entries with ligand similarity: