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Target
Prostaglandin E2 receptor EP4 subtype
Ligand
BDBM50142493
Substrate
n/a
Meas. Tech.
ChEMBL_158454 (CHEMBL763258)
Ki
6.2±n/a nM
Citation
 Elworthy, TR; Kertesz, DJ; Kim, W; Roepel, MG; Quattrocchio-Setti, L; Smith, DB; Tracy, JL; Chow, A; Li, F; Brill, ER; Lach, LK; McGee, D; Yang, DS; Chiou, SS Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization. Bioorg Med Chem Lett 14:1655-9 (2004) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP4 subtype
Synonyms:
PE2R4_HUMAN | PGE receptor EP4 subtype | PGE2 receptor EP4 subtype | PTGER2 | PTGER4 | Prostaglandin E2 receptor | Prostanoid EP4 receptor
Type:
Enzyme
Mol. Mass.:
53134.53
Organism:
Homo sapiens (Human)
Description:
P35408
Residue:
488
Sequence:
MSTPGVNSSASLSPDRLNSPVTIPAVMFIFGVVGNLVAIVVLCKSRKEQKETTFYTLVCGLAVTDLLGTLLVSPVTIATYMKGQWPGGQPLCEYSTFILLFFSLSGLSIICAMSVERYLAINHAYFYSHYVDKRLAGLTLFAVYASNVLFCALPNMGLGSSRLQYPDTWCFIDWTTNVTAHAAYSYMYAGFSSFLILATVLCNVLVCGALLRMHRQFMRRTSLGTEQHHAAAAASVASRGHPAASPALPRLSDFRRRRSFRRIAGAEIQMVILLIATSLVVLICSIPLVVRVFVNQLYQPSLEREVSKNPDLQAIRIASVNPILDPWIYILLRKTVLSKAIEKIKCLFCRIGGSRRERSGQHCSDSQRTSSAMSGHSRSFISRELKEISSTSQTLLPDLSLPDLSENGLGGRNLLPGVPGMGLAQEDTTSLRTLRISETSDSSQGQDSESVLLVDEAGGSGRAGPAPKGSSLQVTFPSETLNLSEKCI
  
Inhibitor
Name:
BDBM50142493
Synonyms:
7-{(R)-2-[(E)-3-(2'-Chloro-biphenyl-3-yl)-3-hydroxy-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid | CHEMBL297578
Type:
Small organic molecule
Emp. Form.:
C26H30ClNO4
Mol. Mass.:
455.974
SMILES:
OC(\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O)c1cccc(c1)-c1ccccc1Cl
Structure:
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