Reaction Details  Report a problem with these data
Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50125409
Substrate
n/a
Meas. Tech.
ChEBML_158328
Ki
20000±n/a nM
Citation
 Elworthy, TR; Kertesz, DJ; Kim, W; Roepel, MG; Quattrocchio-Setti, L; Smith, DB; Tracy, JL; Chow, A; Li, F; Brill, ER; Lach, LK; McGee, D; Yang, DS; Chiou, SS Lactams as EP4 prostanoid receptor subtype selective agonists. Part 1: 2-Pyrrolidinones-stereochemical and lower side-chain optimization. Bioorg Med Chem Lett 14:1655-9 (2004) [PubMed]  Article
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PE2R3_HUMAN | PGE receptor, EP3 subtype | PGE2-R | PTGER3 | Prostaglandin E2 receptor | Prostaglandin E2 receptor EP3 subtype | Prostaglandin E2 receptor EP3 subtype (EP3) | Prostaglandin E2 receptor EP3A subtype (EP3A) | Prostaglandin E2 receptor EP3D subtype (EP3D) | Prostanoid EP3 receptor
Type:
Enzyme
Mol. Mass.:
43335.03
Organism:
Homo sapiens (Human)
Description:
P43115
Residue:
390
Sequence:
MKETRGYGGDAPFCTRLNHSYTGMWAPERSAEARGNLTRPPGSGEDCGSVSVAFPITMLLTGFVGNALAMLLVSRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTTPVVIVVYLSKQRWEHIDPSGRLCTFFGLTMTVFGLSSLFIASAMAVERALAIRAPHWYASHMKTRATRAVLLGVWLAVLAFALLPVLGVGQYTVQWPGTWCFISTGRGGNGTSSSHNWGNLFFASAFAFLGLLALTVTFSCNLATIKALVSRCRAKATASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQTSVEHCKTHTEKQKECNFFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRYHTNNYASSSTSLPCQCSSTLMWSDHLER
  
Inhibitor
Name:
BDBM50125409
Synonyms:
7-{(R)-2-[(E)-3-Hydroxy-3-(1-phenyl-cyclopropyl)-propenyl]-5-oxo-pyrrolidin-1-yl}-heptanoic acid | CHEMBL280223
Type:
Small organic molecule
Emp. Form.:
C23H31NO4
Mol. Mass.:
385.4965
SMILES:
OC(\C=C\[C@H]1CCC(=O)N1CCCCCCC(O)=O)C1(CC1)c1ccccc1
Structure:
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