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Target
Aromatase
Ligand
BDBM50576412
Substrate
n/a
Meas. Tech.
ChEMBL_2127125 (CHEMBL4836470)
IC50
10700±n/a nM
Citation
 Chawengrum, P; Boonsombat, J; Mahidol, C; Eurtivong, C; Kittakoop, P; Thongnest, S; Ruchirawat, S Diterpenoids with Aromatase Inhibitory Activity from the Rhizomes of  J Nat Prod 84:1738-1747 (2021) [PubMed]  Article
Target
Name:
Aromatase
Synonyms:
ARO1 | Aromatase | CP19A_HUMAN | CYAR | CYP19 | CYP19A1 | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 19A1 | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM
Type:
Enzyme
Mol. Mass.:
57888.92
Organism:
Homo sapiens (Human)
Description:
P11511
Residue:
503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
  
Inhibitor
Name:
BDBM50576412
Synonyms:
CHEMBL4859743
Type:
Small organic molecule
Emp. Form.:
C20H32O4
Mol. Mass.:
336.4657
SMILES:
[H][C@@]12CCC3=C[C@@]4(OO[C@]3([C@H](C)O4)[C@@]1(C)CCCC2(C)C)C(C)(C)O |r,t:4|
Structure:
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