Reaction Details  Report a problem with these data
Target
Fibroblast growth factor receptor 1
Ligand
BDBM50577015
Substrate
n/a
Meas. Tech.
ChEMBL_2128597 (CHEMBL4838026)
IC50
2.5±n/a nM
Citation
 Ran, K; Zeng, J; Wan, G; He, X; Feng, Z; Xiang, W; Wei, W; Hu, X; Wang, N; Liu, Z; Yu, L Design, synthesis and biological evaluations of a series of Pyrido[1,2-a]pyrimidinone derivatives as novel selective FGFR inhibitors. Eur J Med Chem 220:0 (2021) [PubMed]  Article
Target
Name:
Fibroblast growth factor receptor 1
Synonyms:
BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr
Type:
Receptor
Mol. Mass.:
91861.70
Organism:
Homo sapiens (Human)
Description:
P11362
Residue:
822
Sequence:
MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEVESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRTRITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNVSDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTSPEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKEFKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENEYGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVEFMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKTAGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHHSAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVSADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFPDTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR
  
Inhibitor
Name:
BDBM50577015
Synonyms:
CHEMBL4851029
Type:
Small organic molecule
Emp. Form.:
C28H34N6O4
Mol. Mass.:
518.6074
SMILES:
COc1cc(OC)cc(c1)N(CCNC1CCC(O)CC1)c1ccc2ncc(-c3cnn(C)c3)c(=O)n2c1 |(74.36,-53.02,;73.03,-53.8,;71.69,-53.03,;71.68,-51.48,;70.33,-50.72,;70.32,-49.18,;71.65,-48.39,;69,-51.5,;69.01,-53.03,;70.35,-53.81,;67.68,-53.81,;67.68,-55.36,;66.35,-56.13,;66.35,-57.67,;65.02,-58.44,;63.69,-57.67,;62.37,-58.44,;62.36,-59.97,;61.03,-60.74,;63.69,-60.75,;65.03,-59.98,;66.33,-53.04,;66.33,-51.49,;64.99,-50.73,;63.66,-51.5,;62.32,-50.74,;60.99,-51.51,;60.98,-53.06,;59.66,-53.83,;59.49,-55.36,;57.99,-55.67,;57.22,-54.34,;55.69,-54.19,;58.25,-53.2,;62.32,-53.83,;62.33,-55.38,;63.66,-53.05,;65,-53.82,)|
Structure:
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