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Target
Tyrosine-protein kinase Mer
Ligand
BDBM497312
Substrate
n/a
Meas. Tech.
ChEMBL_2129273 (CHEMBL4838702)
IC50
2.4±n/a nM
Citation
 Zheng, H; Zhao, J; Li, B; Zhang, W; Stashko, MA; Minson, KA; Huey, MG; Zhou, Y; Earp, HS; Kireev, D; Graham, DK; DeRyckere, D; Frye, SV; Wang, X UNC5293, a potent, orally available and highly MERTK-selective inhibitor. Eur J Med Chem 220:0 (2021) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase Mer
Synonyms:
MER | MER intracellular domain/EGFR extracellular domain chimera | MERTK | MERTK_HUMAN | Proto-oncogene c-Mer | Proto-oncogene tyrosine-protein kinase MER | Receptor tyrosine kinase MerTK | Tyrosine-protein kinase Mer
Type:
PROTEIN
Mol. Mass.:
110234.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1498723
Residue:
999
Sequence:
MGPAPLPLLLGLFLPALWRRAITEAREEAKPYPLFPGPFPGSLQTDHTPLLSLPHASGYQPALMFSPTQPGRPHTGNVAIPQVTSVESKPLPPLAFKHTVGHIILSEHKGVKFNCSISVPNIYQDTTISWWKDGKELLGAHHAITQFYPDDEVTAIIASFSITSVQRSDNGSYICKMKINNEEIVSDPIYIEVQGLPHFTKQPESMNVTRNTAFNLTCQAVGPPEPVNIFWVQNSSRVNEQPEKSPSVLTVPGLTEMAVFSCEAHNDKGLTVSKGVQINIKAIPSPPTEVSIRNSTAHSILISWVPGFDGYSPFRNCSIQVKEADPLSNGSVMIFNTSALPHLYQIKQLQALANYSIGVSCMNEIGWSAVSPWILASTTEGAPSVAPLNVTVFLNESSDNVDIRWMKPPTKQQDGELVGYRISHVWQSAGISKELLEEVGQNGSRARISVQVHNATCTVRIAAVTRGGVGPFSDPVKIFIPAHGWVDYAPSSTPAPGNADPVLIIFGCFCGFILIGLILYISLAIRKRVQETKFGNAFTEEDSELVVNYIAKKSFCRRAIELTLHSLGVSEELQNKLEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKVAVKTMKLDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEKLLESLPDVRNQADVIYVNTQLLESSEGLAQGSTLAPLDLNIDPDSIIASCTPRAAISVVTAEVHDSKPHEGRYILNGGSEEWEDLTSAPSAAVTAEKNSVLPGERLVRNGVSWSHSSMLPLGSSLPDELLFADDSSEGSEVLM
  
Inhibitor
Name:
BDBM497312
Synonyms:
(1S,4r)-4-(5-(1-((2,6- dimethylpyridin-4- yl)methyl)piperidin-4-yl)-2- (((S)-pentan-2-yl)amino)- 7H-pyrrolo[2,3- d]pyrimidin-7- yl)cyclohexan-1-ol | US11001586, Example 90
Type:
Small organic molecule
Emp. Form.:
C30H44N6O
Mol. Mass.:
504.71
SMILES:
CCC[C@H](C)Nc1ncc2c(cn([C@H]3CC[C@H](O)CC3)c2n1)C1CCN(Cc2cc(C)nc(C)c2)CC1 |r,wU:13.12,wD:16.16,3.3,(-8.89,-3.32,;-7.56,-2.55,;-6.22,-3.32,;-4.89,-2.55,;-4.89,-1.01,;-3.55,-3.32,;-2.22,-2.55,;-2.22,-1.01,;-.89,-.24,;.45,-1.01,;1.91,-.54,;2.82,-1.78,;1.91,-3.03,;2.39,-4.5,;3.89,-4.82,;4.37,-6.28,;3.34,-7.42,;3.82,-8.89,;1.83,-7.1,;1.36,-5.64,;.45,-2.55,;-.89,-3.32,;2.39,.93,;3.89,1.25,;4.37,2.71,;3.34,3.86,;3.82,5.32,;5.32,5.64,;5.8,7.1,;7.3,7.42,;7.78,8.89,;8.33,6.28,;7.86,4.82,;8.89,3.67,;6.35,4.5,;1.83,3.53,;1.36,2.07,)|
Structure:
Search PDB for entries with ligand similarity: