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Target
Arginase-1
Ligand
BDBM50577464
Substrate
n/a
Meas. Tech.
ChEMBL_2130269 (CHEMBL4839698)
IC50
20±n/a nM
Citation
 Lu, M; Zhang, H; Li, D; Childers, M; Pu, Q; Palte, RL; Gathiaka, S; Lyons, TW; Palani, A; Fan, PW; Spacciapoli, P; Miller, JR; Cho, H; Cheng, M; Chakravarthy, K; O'Neil, J; Eangoor, P; Beard, A; Kim, HY; Saurí, J; Gunaydin, H; Sloman, DL; Siliphaivanh, P; Cumming, J; Fischer, C Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology. ACS Med Chem Lett 12:1380-1388 (2021) [PubMed]  Article
Target
Name:
Arginase-1
Synonyms:
ARG1 | ARGI1_HUMAN | Liver-type arginase | Type I arginase
Type:
PROTEIN
Mol. Mass.:
34737.53
Organism:
Homo sapiens (Human)
Description:
ChEMBL_978893
Residue:
322
Sequence:
MSAKSRTIGIIGAPFSKGQPRGGVEEGPTVLRKAGLLEKLKEQECDVKDYGDLPFADIPNDSPFQIVKNPRSVGKASEQLAGKVAEVKKNGRISLVLGGDHSLAIGSISGHARVHPDLGVIWVDAHTDINTPLTTTSGNLHGQPVSFLLKELKGKIPDVPGFSWVTPCISAKDIVYIGLRDVDPGEHYILKTLGIKYFSMTEVDRLGIGKVMEETLSYLLGRKKRPIHLSFDVDGLDPSFTPATGTPVVGGLTYREGLYITEEIYKTGLLSGLDIMEVNPSLGKTPEEVTRTVNTAVAITLACFGLAREGNHKPIDYLNPPK
  
Inhibitor
Name:
BDBM50577464
Synonyms:
CHEMBL4863489
Type:
Small organic molecule
Emp. Form.:
C9H19BN2O4
Mol. Mass.:
230.069
SMILES:
CN[C@H]1CN[C@@H]([C@@H]1CCCB(O)O)C(O)=O |r|
Structure:
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