Target
Tyrosine-protein kinase receptor UFO
Ligand
BDBM50578097
Substrate
n/a
Meas. Tech.
ChEMBL_2131990 (CHEMBL4841505)
IC50
70000±n/a nM
Citation
 Ng, PSFoo, KSim, SWang, GHuang, CTan, LHPoulsen, ALiu, BTee, DHYAhmad, NHBWang, SKe, ZLee, MAKwek, ZPJoy, JAnantharajan, JBaburajendran, NPendharkar, VManoharan, VVuddagiri, SSangthongpitag, KHill, JKeller, THHung, AW Fragment-based lead discovery of indazole-based compounds as AXL kinase inhibitors. Bioorg Med Chem 49:0 (2021) [PubMed]  Article
Target
Name:
Tyrosine-protein kinase receptor UFO
Synonyms:
AXL | AXL oncogene | TEL/AXL | Tyrosine-protein kinase receptor UFO (AXL) | UFO | UFO_HUMAN
Type:
Enzyme
Mol. Mass.:
98316.97
Organism:
Homo sapiens (Human)
Description:
P30530
Residue:
894
Sequence:
MAWRCPRMGRVPLAWCLALCGWACMAPRGTQAEESPFVGNPGNITGARGLTGTLRCQLQVQGEPPEVHWLRDGQILELADSTQTQVPLGEDEQDDWIVVSQLRITSLQLSDTGQYQCLVFLGHQTFVSQPGYVGLEGLPYFLEEPEDRTVAANTPFNLSCQAQGPPEPVDLLWLQDAVPLATAPGHGPQRSLHVPGLNKTSSFSCEAHNAKGVTTSRTATITVLPQQPRNLHLVSRQPTELEVAWTPGLSGIYPLTHCTLQAVLSDDGMGIQAGEPDPPEEPLTSQASVPPHQLRLGSLHPHTPYHIRVACTSSQGPSSWTHWLPVETPEGVPLGPPENISATRNGSQAFVHWQEPRAPLQGTLLGYRLAYQGQDTPEVLMDIGLRQEVTLELQGDGSVSNLTVCVAAYTAAGDGPWSLPVPLEAWRPGQAQPVHQLVKEPSTPAFSWPWWYVLLGAVVAAACVLILALFLVHRRKKETRYGEVFEPTVERGELVVRYRVRKSYSRRTTEATLNSLGISEELKEKLRDVMVDRHKVALGKTLGEGEFGAVMEGQLNQDDSILKVAVKTMKIAICTRSELEDFLSEAVCMKEFDHPNVMRLIGVCFQGSERESFPAPVVILPFMKHGDLHSFLLYSRLGDQPVYLPTQMLVKFMADIASGMEYLSTKRFIHRDLAARNCMLNENMSVCVADFGLSKKIYNGDYYRQGRIAKMPVKWIAIESLADRVYTSKSDVWSFGVTMWEIATRGQTPYPGVENSEIYDYLRQGNRLKQPADCLDGLYALMSRCWELNPQDRPSFTELREDLENTLKALPPAQEPDEILYVNMDEGGGYPEPPGAAGGADPPTQPDPKDSCSCLTAAEVHPAGRYVLCPSTTPSPAQPADRGSPAAPGQEDGA
  
Inhibitor
Name:
BDBM50578097
Synonyms:
CHEMBL4876336
Type:
Small organic molecule
Emp. Form.:
C11H11NO2S
Mol. Mass.:
221.276
SMILES:
Cc1ccc(C)n1-c1ccsc1C(O)=O |(66.7,-6.21,;67.4,-7.57,;66.71,-8.94,;67.8,-10.03,;69.17,-9.33,;70.54,-10.02,;68.93,-7.8,;70.01,-6.7,;71.53,-6.93,;72.23,-5.56,;71.14,-4.47,;69.77,-5.18,;68.4,-4.48,;67.11,-5.32,;68.31,-2.95,)|
Structure:
Search PDB for entries with ligand similarity: