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Target
Indoleamine 2,3-dioxygenase 1
Ligand
BDBM50578624
Substrate
n/a
Meas. Tech.
ChEMBL_2133699 (CHEMBL4843309)
IC50
25±n/a nM
Citation
 Hamilton, MM; Mseeh, F; McAfoos, TJ; Leonard, PG; Reyna, NJ; Harris, AL; Xu, A; Han, M; Soth, MJ; Czako, B; Theroff, JP; Mandal, PK; Burke, JP; Virgin-Downey, B; Petrocchi, A; Pfaffinger, D; Rogers, NE; Parker, CA; Yu, SS; Jiang, Y; Krapp, S; Lammens, A; Trevitt, G; Tremblay, MR; Mikule, K; Wilcoxen, K; Cross, JB; Jones, P; Marszalek, JR; Lewis, RT Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme. J Med Chem 64:11302-11329 (2021) [PubMed]  Article
Target
Name:
Indoleamine 2,3-dioxygenase 1
Synonyms:
I23O1_MOUSE | IDO-1 | Ido | Ido1 | Indo | Indoleamine-pyrrole 2,3-dioxygenase
Type:
PROTEIN
Mol. Mass.:
45639.39
Organism:
Mus musculus
Description:
ChEMBL_1452149
Residue:
407
Sequence:
MALSKISPTEGSRRILEDHHIDEDVGFALPHPLVELPDAYSPWVLVARNLPVLIENGQLREEVEKLPTLSTDGLRGHRLQRLAHLALGYITMAYVWNRGDDDVRKVLPRNIAVPYCELSEKLGLPPILSYADCVLANWKKKDPNGPMTYENMDILFSFPGGDCDKGFFLVSLLVEIAASPAIKAIPTVSSAVERQDLKALEKALHDIATSLEKAKEIFKRMRDFVDPDTFFHVLRIYLSGWKCSSKLPEGLLYEGVWDTPKMFSGGSAGQSSIFQSLDVLLGIKHEAGKESPAEFLQEMREYMPPAHRNFLFFLESAPPVREFVISRHNEDLTKAYNECVNGLVSVRKFHLAIVDTYIMKPSKKKPTDGDKSEEPSNVESRGTGGTNPMTFLRSVKDTTEKALLSWP
  
Inhibitor
Name:
BDBM50578624
Synonyms:
CHEMBL4856710
Type:
Small organic molecule
Emp. Form.:
C24H22ClFN2O
Mol. Mass.:
408.896
SMILES:
[H][C@@]12C[C@H](C[C@]1([H])[C@H]2C(C)NC(=O)c1ccc(Cl)cc1)c1ccnc2ccc(F)cc12 |r|
Structure:
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