Reaction Details  Report a problem with these data
Target
Neuromedin-B receptor
Ligand
BDBM50147034
Substrate
n/a
Meas. Tech.
ChEBML_143203
IC50
>10000±n/a nM
Citation
 Shuttleworth, SJ; Lizarzaburu, ME; Chai, A; Coward, P Identification and optimization of novel partial agonists of neuromedin B receptor using parallel synthesis. Bioorg Med Chem Lett 14:3037-42 (2004) [PubMed]  Article
Target
Name:
Neuromedin-B receptor
Synonyms:
Bombesin 1 | NMB-R | NMBR | NMBR_HUMAN | Neuromedin B | Neuromedin B receptor | Neuromedin-B receptor | Neuromedin-B-preferring bombesin receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
43447.11
Organism:
Homo sapiens (Human)
Description:
Bombesin 1 NMBR 0::P28336
Residue:
390
Sequence:
MPSKSLSNLSVTTGANESGSVPEGWERDFLPASDGTTTELVIRCVIPSLYLLIITVGLLGNIMLVKIFITNSAMRSVPNIFISNLAAGDLLLLLTCVPVDASRYFFDEWMFGKVGCKLIPVIQLTSVGVSVFTLTALSADRYRAIVNPMDMQTSGALLRTCVKAMGIWVVSVLLAVPEAVFSEVARISSLDNSSFTACIPYPQTDELHPKIHSVLIFLVYFLIPLAIISIYYYHIAKTLIKSAHNLPGEYNEHTKKQMETRKRLAKIVLVFVGCFIFCWFPNHILYMYRSFNYNEIDPSLGHMIVTLVARVLSFGNSCVNPFALYLLSESFRRHFNSQLCCGRKSYQERGTSYLLSSSAVRMTSLKSNAKNMVTNSVLLNGHSMKQEMAL
  
Inhibitor
Name:
BDBM50147034
Synonyms:
3-[3-(4-Nitro-phenyl)-ureido]-2,3,4,9-tetrahydro-1H-carbazole-3-carboxylic acid (2-pyridin-2-yl-ethyl)-amide | CHEMBL419174
Type:
Small organic molecule
Emp. Form.:
C27H26N6O4
Mol. Mass.:
498.5331
SMILES:
[O-][N+](=O)c1ccc(NC(=O)NC2(CCc3[nH]c4ccccc4c3C2)C(=O)NCCc2ccccn2)cc1
Structure:
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