Reaction Details 
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E3 ubiquitin-protein ligase Mdm2
Ligand
BDBM50434287
Substrate
n/a
Meas. Tech.
ChEMBL_2145773 (CHEMBL5030053)
Kd
11±n/a nM
Citation
Reutershan, MH; Machacek, MR; Altman, MD; Bogen, S; Cai, M; Cammarano, C; Chen, D; Christopher, M; Cryan, J; Daublain, P; Fradera, X; Geda, P; Goldenblatt, P; Hill, AD; Kemper, RA; Kutilek, V; Li, C; Martinez, M; McCoy, M; Nair, L; Pan, W; Thompson, CF; Scapin, G; Shizuka, M; Spatz, ML; Steinhuebel, D; Sun, B; Voss, ME; Wang, X; Yang, L; Yeh, TC; Dussault, I; Marshall, CG; Trotter, BW Discovery of J Med Chem 64:16213-16241 (2021) [PubMed] ArticleMore Info.:
Target
Name:
E3 ubiquitin-protein ligase Mdm2
Synonyms:
Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein
Type:
Oncoprotein
Mol. Mass.:
55196.54
Organism:
Homo sapiens (Human)
Description:
Q00987
Residue:
491
Sequence:
MCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSENRCHLEGGSDQKDLVQELQEEKPSSSHLVSRPSTSSRRRAISETEENSDELSGERQRKRHKSDSISLSFDESLALCVIREICCERSSSSESTGTPSNPDLDAGVSEHSGDWLDQDSVSDQFSVEFEVESLDSEDYSLSEEGQELSDEDDEVYQVTVYQAGESDTDSFEEDPEISLADYWKCTSCNEMNPPLPSHCNRCWALRENWLPEDKGKDKGEISEKAKLENSTQAEEGFDVPDCKKTIVNDSRESCVEENDDKITQASQSQESEDYSQPSTSSSIIYSSQEDVKEFEREETQDKEESVESSLPLNAIEPCVICQGRPKNGCIVHGKTGHLMACFTCAKKLKKRNKPCPVCRQPIQMIVLTYFP
Inhibitor
Name:
BDBM50434287
Synonyms:
CHEMBL2386346
Type:
Small organic molecule
Emp. Form.:
C38H48Cl2N4O4S
Mol. Mass.:
727.783
SMILES:
CCOc1cc(ccc1C1=N[C@@](C)(c2ccc(Cl)cc2)[C@](C)(N1C(=O)N1CCN(CCCS(C)(=O)=O)CC1)c1ccc(Cl)cc1)C(C)(C)C |r,t:10|
Structure:
