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Target
D(2) dopamine receptor
Ligand
BDBM50147374
Substrate
n/a
Meas. Tech.
ChEBML_60067
Ki
8000±n/a nM
Citation
 Beaulieu, C; Wang, Z; Denis, D; Greig, G; Lamontagne, S; O'Neill, G; Slipetz, D; Wang, J Benzimidazoles as new potent and selective DP antagonists for the treatment of allergic rhinitis. Bioorg Med Chem Lett 14:3195-9 (2004) [PubMed]  Article
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50147374
Synonyms:
4-[1-(4-Chloro-benzyl)-1H-benzoimidazol-2-yl]-benzoic acid methyl ester | CHEMBL108243
Type:
Small organic molecule
Emp. Form.:
C22H17ClN2O2
Mol. Mass.:
376.836
SMILES:
COC(=O)c1ccc(cc1)-c1nc2ccccc2n1Cc1ccc(Cl)cc1
Structure:
Search PDB for entries with ligand similarity: