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Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50580184
Substrate
n/a
Meas. Tech.
ChEMBL_2147395 (CHEMBL5031741)
Ki
16±n/a nM
Citation
 Barbaraci, C; Giurdanella, G; Leotta, CG; Longo, A; Amata, E; Dichiara, M; Pasquinucci, L; Turnaturi, R; Prezzavento, O; Cacciatore, I; Zuccarello, E; Lupo, G; Pitari, GM; Anfuso, CD; Marrazzo, A Haloperidol Metabolite II Valproate Ester ( J Med Chem 64:13622-13632 (2021) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50580184
Synonyms:
CHEMBL5079556
Type:
Small organic molecule
Emp. Form.:
C29H39ClFNO3
Mol. Mass.:
504.076
SMILES:
CCCC(CCC)C(=O)O[C@@H](CCCN1CCC(O)(CC1)c1ccc(Cl)cc1)c1ccc(F)cc1 |r|
Structure:
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