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Target
Sodium-dependent dopamine transporter
Ligand
BDBM84745
Substrate
n/a
Meas. Tech.
ChEMBL_61520 (CHEMBL674998)
Ki
240±n/a nM
Citation
 Kuo, F; Gillespie, TA; Kulanthaivel, P; Lantz, RJ; Ma, TW; Nelson, DL; Threlkeld, PG; Wheeler, WJ; Yi, P; Zmijewski, M Synthesis and biological activity of some known and putative duloxetine metabolites. Bioorg Med Chem Lett 14:3481-6 (2004) [PubMed]  Article
Target
Name:
Sodium-dependent dopamine transporter
Synonyms:
DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3
Type:
Multi-pass membrane protein
Mol. Mass.:
68497.11
Organism:
Homo sapiens (Human)
Description:
Q01959
Residue:
620
Sequence:
MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDRETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELALGQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHCNNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQLTACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSVDFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSSGFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGIDSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAAGTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSIVTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKDRELVDRGEVRQFTLRHWLKV
  
Inhibitor
Name:
BDBM84745
Synonyms:
CAS_136434-34-9 | DULOXETINE | LY-248686 | LY248686 | USRE49340, Rank 5
Type:
Small organic molecule
Emp. Form.:
C18H19NOS
Mol. Mass.:
297.415
SMILES:
CNCC[C@H](Oc1cccc2ccccc12)c1cccs1 |r|
Structure:
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