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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50580857
Substrate
n/a
Meas. Tech.
ChEMBL_2149105 (CHEMBL5033503)
IC50
>20000±n/a nM
Citation
 Xiao, T; Sun, L; Zhang, M; Li, Z; Haura, EB; Schonbrunn, E; Ji, H Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg Med Chem Lett 51:0 (2021) [PubMed]  Article
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50580857
Synonyms:
CHEMBL5088383
Type:
Small organic molecule
Emp. Form.:
C39H46N4O6
Mol. Mass.:
666.8057
SMILES:
COC(=O)Cc1ccc(cc1)[C@@H]1CC(=O)NC2(CCCCC2)C(=O)N[C@@H](CC(N)=O)C(=O)NC[C@H](Cc2cccc3ccccc23)C\C=C\1 |r,t:51|
Structure:
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