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Target
Growth factor receptor-bound protein 2
Ligand
BDBM50060523
Substrate
n/a
Meas. Tech.
ChEMBL_2149110 (CHEMBL5033508)
IC50
8640±n/a nM
Citation
 Xiao, T; Sun, L; Zhang, M; Li, Z; Haura, EB; Schonbrunn, E; Ji, H Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg Med Chem Lett 51:0 (2021) [PubMed]  Article
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50060523
Synonyms:
CHEMBL118574 | Phosphoric acid mono-(4-{(S)-2-acetylamino-2-[(1S,2S)-1-((S)-1,2-dicarbamoyl-ethylcarbamoyl)-2-methyl-butylcarbamoyl]-ethyl}-phenyl) ester
Type:
Small organic molecule
Emp. Form.:
C21H32N5O9P
Mol. Mass.:
529.4806
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(OP(O)(O)=O)cc1)NC(C)=O)C(=O)N[C@@H](CC(N)=O)C(N)=O
Structure:
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