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Target
Glutaminyl-peptide cyclotransferase
Ligand
BDBM50581443
Substrate
n/a
Meas. Tech.
ChEMBL_2151037 (CHEMBL5035499)
IC50
1.6±n/a nM
Citation
 Van Manh, N; Hoang, VH; Ngo, VTH; Ann, J; Jang, TH; Ha, JH; Song, JY; Ha, HJ; Kim, H; Kim, YH; Lee, J; Lee, J Discovery of highly potent human glutaminyl cyclase (QC) inhibitors as anti-Alzheimer's agents by the combination of pharmacophore-based and structure-based design. Eur J Med Chem 226:0 (2021) [PubMed]  Article
Target
Name:
Glutaminyl-peptide cyclotransferase
Synonyms:
Glutaminyl Cyclase | Glutaminyl cyclase (QC) | Glutaminyl-peptide cyclotransferase | Glutaminyl-peptide cyclotransferase precursor (QC) | Glutaminyl-tRNA cyclotransferase | Glutamyl cyclase (QC) | QPCT | QPCT_HUMAN
Type:
Enzyme
Mol. Mass.:
40877.05
Organism:
Homo sapiens (Human)
Description:
Q16769
Residue:
361
Sequence:
MAGGRHRRVVGTLHLLLLVAALPWASRGVSPSASAWPEEKNYHQPAILNSSALRQIAEGTSISEMWQNDLQPLLIERYPGSPGSYAARQHIMQRIQRLQADWVLEIDTFLSQTPYGYRSFSNIISTLNPTAKRHLVLACHYDSKYFSHWNNRVFVGATDSAVPCAMMLELARALDKKLLSLKTVSDSKPDLSLQLIFFDGEEAFLHWSPQDSLYGSRHLAAKMASTPHPPGARGTSQLHGMDLLVLLDLIGAPNPTFPNFFPNSARWFERLQAIEHELHELGLLKDHSLEGRYFQNYSYGGVIQDDHIPFLRRGVPVLHLIPSPFPEVWHTMDDNEENLDESTIDNLNKILQVFVLEYLHL
  
Inhibitor
Name:
BDBM50581443
Synonyms:
CHEMBL5083687
Type:
Small organic molecule
Emp. Form.:
C27H43N7O3
Mol. Mass.:
513.6754
SMILES:
COc1cc(ccc1OCCN1CCNCC1)N(C1CCN(C)CC1)C(=O)NCCCn1cncc1C
Structure:
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