Reaction Details 
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E3 ubiquitin-protein ligase CBL-B
Ligand
BDBM50581858
Substrate
n/a
Meas. Tech.
ChEMBL_2152485 (CHEMBL5037032)
IC50
6500±n/a nM
Citation
Jiang, W; Wang, D; Wilson, BAP; Voeller, D; Bokesch, HR; Smith, EA; Lipkowitz, S; O'Keefe, BR; Gustafson, KR Sinularamides A-G, Terpenoid-Derived Spermidine and Spermine Conjugates with Casitas B-Lineage Lymphoma Proto-Oncogene B (Cbl-b) Inhibitory Activities from a J Nat Prod 84:1831-1837 (2021) [PubMed] ArticleMore Info.:
Target
Name:
E3 ubiquitin-protein ligase CBL-B
Synonyms:
2.3.2.27 | CBLB | CBLB_HUMAN | Casitas B-lineage lymphoma proto-oncogene b | RING finger protein 56 | RING-type E3 ubiquitin transferase CBL-B | RNF56 | SH3-binding protein CBL-B | Signal transduction protein CBL-B
Type:
PROTEIN
Mol. Mass.:
109467.65
Organism:
Homo sapiens
Description:
ChEMBL_120423
Residue:
982
Sequence:
MANSMNGRNPGGRGGNPRKGRILGIIDAIQDAVGPPKQAAADRRTVEKTWKLMDKVVRLCQNPKLQLKNSPPYILDILPDTYQHLRLILSKYDDNQKLAQLSENEYFKIYIDSLMKKSKRAIRLFKEGKERMYEEQSQDRRNLTKLSLIFSHMLAEIKAIFPNGQFQGDNFRITKADAAEFWRKFFGDKTIVPWKVFRQCLHEVHQISSGLEAMALKSTIDLTCNDYISVFEFDIFTRLFQPWGSILRNWNFLAVTHPGYMAFLTYDEVKARLQKYSTKPGSYIFRLSCTRLGQWAIGYVTGDGNILQTIPHNKPLFQALIDGSREGFYLYPDGRSYNPDLTGLCEPTPHDHIKVTQEQYELYCEMGSTFQLCKICAENDKDVKIEPCGHLMCTSCLTAWQESDGQGCPFCRCEIKGTEPIIVDPFDPRDEGSRCCSIIDPFGMPMLDLDDDDDREESLMMNRLANVRKCTDRQNSPVTSPGSSPLAQRRKPQPDPLQIPHLSLPPVPPRLDLIQKGIVRSPCGSPTGSPKSSPCMVRKQDKPLPAPPPPLRDPPPPPPERPPPIPPDNRLSRHIHHVESVPSRDPPMPLEAWCPRDVFGTNQLVGCRLLGEGSPKPGITASSNVNGRHSRVGSDPVLMRKHRRHDLPLEGAKVFSNGHLGSEEYDVPPRLSPPPPVTTLLPSIKCTGPLANSLSEKTRDPVEEDDDEYKIPSSHPVSLNSQPSHCHNVKPPVRSCDNGHCMLNGTHGPSSEKKSNIPDLSIYLKGDVFDSASDPVPLPPARPPTRDNPKHGSSLNRTPSDYDLLIPPLGEDAFDALPPSLPPPPPPARHSLIEHSKPPGSSSRPSSGQDLFLLPSDPFVDLASGQVPLPPARRLPGENVKTNRTSQDYDQLPSCSDGSQAPARPPKPRPRRTAPEIHHRKPHGPEAALENVDAKIAKLMGEGYAFEEVKRALEIAQNNVEVARSILREFAFPPPVSPRLNL
Inhibitor
Name:
BDBM50581858
Synonyms:
CHEMBL5087523
Type:
Small organic molecule
Emp. Form.:
C34H66N4O
Mol. Mass.:
546.9129
SMILES:
[#6]\[#6](-[#6])=[#6]/[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6]-[#6]\[#6](-[#6])=[#6]\[#6](=O)-[#7]-[#6]-[#6]-[#6][N+]([#6])([#6])[#6]-[#6]-[#6]-[#6][N+]([#6])([#6])[#6]-[#6]-[#6]-[#7]
Structure:
