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Target
Polyunsaturated fatty acid lipoxygenase ALOX12
Ligand
BDBM50150793
Substrate
n/a
Meas. Tech.
ChEMBL_305339 (CHEMBL833559)
IC50
10000±n/a nM
Citation
 Segraves, EN; Shah, RR; Segraves, NL; Johnson, TA; Whitman, S; Sui, JK; Kenyon, VA; Cichewicz, RH; Crews, P; Holman, TR Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. J Med Chem 47:4060-5 (2004) [PubMed]  Article
Target
Name:
Polyunsaturated fatty acid lipoxygenase ALOX12
Synonyms:
12-LOX | 12-Lipoxygenase (12-LOX) | 12LO | ALOX12 | Arachidonate 12-lipoxygenase | Arachidonate 12-lipoxygenase, 12S-type | LOG12 | LOX12_HUMAN | Platelet 12-lipoxygenase | Platelet-type lipoxygenase 12
Type:
Protein
Mol. Mass.:
75689.18
Organism:
Homo sapiens (Human)
Description:
P18054
Residue:
663
Sequence:
MGRYRIRVATGAWLFSGSYNRVQLWLVGTRGEAELELQLRPARGEEEEFDHDVAEDLGLLQFVRLRKHHWLVDDAWFCDRITVQGPGACAEVAFPCYRWVQGEDILSLPEGTARLPGDNALDMFQKHREKELKDRQQIYCWATWKEGLPLTIAADRKDDLPPNMRFHEEKRLDFEWTLKAGALEMALKRVYTLLSSWNCLEDFDQIFWGQKSALAEKVRQCWQDDELFSYQFLNGANPMLLRRSTSLPSRLVLPSGMEELQAQLEKELQNGSLFEADFILLDGIPANVIRGEKQYLAAPLVMLKMEPNGKLQPMVIQIQPPNPSSPTPTLFLPSDPPLAWLLAKSWVRNSDFQLHEIQYHLLNTHLVAEVIAVATMRCLPGLHPIFKFLIPHIRYTMEINTRARTQLISDGGIFDKAVSTGGGGHVQLLRRAAAQLTYCSLCPPDDLADRGLLGLPGALYAHDALRLWEIIARYVEGIVHLFYQRDDIVKGDPELQAWCREITEVGLCQAQDRGFPVSFQSQSQLCHFLTMCVFTCTAQHAAINQGQLDWYAWVPNAPCTMRMPPPTTKEDVTMATVMGSLPDVRQACLQMAISWHLSRRQPDMVPLGHHKEKYFSGPKPKAVLNQFRTDLEKLEKEITARNEQLDWPYEYLKPSCIENSVTI
  
Inhibitor
Name:
BDBM50150793
Synonyms:
2,2',6,6'-Tetrabromobisphenol A | 2,2-Bis(3,5-dibromo-4-hydroxyphenyl)propane | 3,3',5,5'-tetrabromobisphenol A | 4,4'-(1-Methylethylidene)bis(2,6-dibromophenol) | 4,4'-(2,2-propanediyl) bis[2,6-dibromo]phenol | 4,4'-(propane-2,2-diyl)bis(2,6-dibromophenol) | 4,4'-Isopropylidenebis(2,6-dibromophenol) | CHEMBL184450
Type:
Small organic molecule
Emp. Form.:
C15H12Br4O2
Mol. Mass.:
543.871
SMILES:
CC(C)(c1cc(Br)c(O)c(Br)c1)c1cc(Br)c(O)c(Br)c1
Structure:
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