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Target
Hydroxyacylglutathione hydrolase, mitochondrial
Ligand
BDBM50582857
Substrate
n/a
Meas. Tech.
ChEMBL_2156027 (CHEMBL5040687)
IC50
52000±n/a nM
Citation
 Legru, A; Verdirosa, F; Hernandez, JF; Tassone, G; Sannio, F; Benvenuti, M; Conde, PA; Bossis, G; Thomas, CA; Crowder, MW; Dillenberger, M; Becker, K; Pozzi, C; Mangani, S; Docquier, JD; Gavara, L 1,2,4-Triazole-3-thione compounds with a 4-ethyl alkyl/aryl sulfide substituent are broad-spectrum metallo-?-lactamase inhibitors with re-sensitization activity. Eur J Med Chem 226:0 (2021) [PubMed]  Article
Target
Name:
Hydroxyacylglutathione hydrolase, mitochondrial
Synonyms:
GLO2 | GLO2_HUMAN | Glyoxalase II | HAGH | HAGH1
Type:
PROTEIN
Mol. Mass.:
33815.06
Organism:
Homo sapiens (Human)
Description:
ChEMBL_71296
Residue:
308
Sequence:
MVVGRGLLGRRSLAALGAACARRGLGPALLGVFCHTDLRKNLTVDEGTMKVEVLPALTDNYMYLVIDDETKEAAIVDPVQPQKVVDAARKHGVKLTTVLTTHHHWDHAGGNEKLVKLESGLKVYGGDDRIGALTHKITHLSTLQVGSLNVKCLATPCHTSGHICYFVSKPGGSEPPAVFTGDTLFVAGCGKFYEGTADEMCKALLEVLGRLPPDTRVYCGHEYTINNLKFARHVEPGNAAIREKLAWAKEKYSIGEPTVPSTLAEEFTYNPFMRVREKTVQQHAGETDPVTTMRAVRREKDQFKMPRD
  
Inhibitor
Name:
BDBM50582857
Synonyms:
CHEMBL5091922
Type:
Small organic molecule
Emp. Form.:
C17H17N3S2
Mol. Mass.:
327.467
SMILES:
S=c1[nH]nc(-c2ccccc2)n1CCSCc1ccccc1
Structure:
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