Reaction Details  Report a problem with these data
Target
Ribosomal protein S6 kinase beta-2
Ligand
BDBM50583520
Substrate
n/a
Meas. Tech.
ChEMBL_2157590 (CHEMBL5042250)
IC50
1650±n/a nM
Citation
 M Serafim, RA; da Silva Santiago, A; Schwalm, MP; Hu, Z; Dos Reis, CV; Takarada, JE; Mezzomo, P; Massirer, KB; Kudolo, M; Gerstenecker, S; Chaikuad, A; Zender, L; Knapp, S; Laufer, S; Couņago, RM; Gehringer, M Development of the First Covalent Monopolar Spindle Kinase 1 (MPS1/TTK) Inhibitor. J Med Chem 65:3173-3192 (2022) [PubMed]  Article
Target
Name:
Ribosomal protein S6 kinase beta-2
Synonyms:
KS6B2_HUMAN | RPS6KB2 | Ribosomal protein S6 kinase (P70S6K) | STK14B
Type:
PROTEIN
Mol. Mass.:
53460.10
Organism:
Homo sapiens (Human)
Description:
ChEMBL_306115
Residue:
482
Sequence:
MAAVFDLDLETEEGSEGEGEPELSPADACPLAELRAAGLEPVGHYEEVELTETSVNVGPERIGPHCFELLRVLGKGGYGKVFQVRKVQGTNLGKIYAMKVLRKAKIVRNAKDTAHTRAERNILESVKHPFIVELAYAFQTGGKLYLILECLSGGELFTHLEREGIFLEDTACFYLAEITLALGHLHSQGIIYRDLKPENIMLSSQGHIKLTDFGLCKESIHEGAVTHTFCGTIEYMAPEILVRSGHNRAVDWWSLGALMYDMLTGSPPFTAENRKKTMDKIIRGKLALPPYLTPDARDLVKKFLKRNPSQRIGGGPGDAADVQRHPFFRHMNWDDLLAWRVDPPFRPCLQSEEDVSQFDTRFTRQTPVDSPDDTALSESANQAFLGFTYVAPSVLDSIKEGFSFQPKLRSPRRLNSSPRAPVSPLKFSPFEGFRPSPSLPEPTELPLPPLLPPPPPSTTAPLPIRPPSGTKKSKRGRGRPGR
  
Inhibitor
Name:
BDBM50583520
Synonyms:
CHEMBL5094006
Type:
Small organic molecule
Emp. Form.:
C35H40N8O2
Mol. Mass.:
604.7445
SMILES:
CCc1cccc(CC)c1NC(=O)c1ccn-2c1CCc1cnc(Nc3ccc(cc3NC(=O)C=C)N3CCN(C)CC3)nc-21
Structure:
Search PDB for entries with ligand similarity: