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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50583659
Substrate
n/a
Meas. Tech.
ChEMBL_2157998 (CHEMBL5042748)
IC50
5.9±n/a nM
Citation
 Tormählen, NM; Martorelli, M; Kuhn, A; Maier, F; Guezguez, J; Burnet, M; Albrecht, W; Laufer, SA; Koch, P Design and Synthesis of Highly Selective Brain Penetrant p38? Mitogen-Activated Protein Kinase Inhibitors. J Med Chem 65:1225-1242 (2022) [PubMed]  Article
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50583659
Synonyms:
CHEMBL5077679
Type:
Small organic molecule
Emp. Form.:
C29H27F2N3O3
Mol. Mass.:
503.5398
SMILES:
Fc1ccc(Nc2ccc3c(CCc4ccc(cc4C3=O)C(=O)NCCN3CC4(COC4)C3)c2)c(F)c1
Structure:
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