Reaction Details  Report a problem with these data
Target
Carbonic anhydrase 2
Ligand
BDBM50174039
Substrate
n/a
Meas. Tech.
ChEMBL_2159349 (CHEMBL5044099)
Ki
0.890000±n/a nM
Citation
 Vannozzi, G; Vullo, D; Angeli, A; Ferraroni, M; Combs, J; Lomelino, C; Andring, J; Mckenna, R; Bartolucci, G; Pallecchi, M; Lucarini, L; Sgambellone, S; Masini, E; Carta, F; Supuran, CT One-Pot Procedure for the Synthesis of Asymmetric Substituted Ureido Benzene Sulfonamides as Effective Inhibitors of Carbonic Anhydrase Enzymes. J Med Chem 65:824-837 (2022) [PubMed]  Article
Target
Name:
Carbonic anhydrase 2
Synonyms:
CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II)
Type:
Enzyme
Mol. Mass.:
29250.71
Organism:
Homo sapiens (Human)
Description:
P00918
Residue:
260
Sequence:
MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRILNNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHLVHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDPRGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELMVDNWRPAQPLKNRQIKASFK
  
Inhibitor
Name:
BDBM50174039
Synonyms:
3-(3-Phenyl-ureido)-benzenesulfonamide | CHEMBL370526
Type:
Small organic molecule
Emp. Form.:
C13H13N3O3S
Mol. Mass.:
291.326
SMILES:
NS(=O)(=O)c1cccc(NC(=O)Nc2ccccc2)c1
Structure:
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