Reaction Details  Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50128110
Substrate
n/a
Meas. Tech.
ChEMBL_2162475 (CHEMBL5047336)
Ki
0.860000±n/a nM
Citation
 Abatematteo, FS; Mosier, PD; Niso, M; Brunetti, L; Berardi, F; Loiodice, F; Contino, M; Delprat, B; Maurice, T; Laghezza, A; Abate, C Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (? Eur J Med Chem 228:0 (2022) [PubMed]  Article
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
OPRS1 | SGMR1_CAVPO | SIGMAR1 | Sigma 1-type opioid receptor | Sigma non-opioid intracellular receptor 1 | Sigma-1 receptor | Sigma1-receptor | Sigma1R | Sterol isomerase-like protein
Type:
Protein
Mol. Mass.:
25307.17
Organism:
Cavia porcellus (Guinea pig)
Description:
Q60492
Residue:
223
Sequence:
MQWAVGRRWLWVALFLAAVAVLTQIVWLWLGTQNFVFQREEIAQLARQYAGLDHELAFSKLIVELRRLHPVHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSPRHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLGFALADTVFSTQDFLTLFYTLRVYARALQLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50128110
Synonyms:
1-[2-(4-Chloro-phenoxy)-ethyl]-4-methyl-piperidine; hydrochloride | CHEMBL543821
Type:
Small organic molecule
Emp. Form.:
C14H20ClNO
Mol. Mass.:
253.768
SMILES:
CC1CCN(CCOc2ccc(Cl)cc2)CC1
Structure:
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