Reaction Details  Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM50128108
Substrate
n/a
Meas. Tech.
ChEMBL_2162476 (CHEMBL5047337)
Ki
52±n/a nM
Citation
 Abatematteo, FS; Mosier, PD; Niso, M; Brunetti, L; Berardi, F; Loiodice, F; Contino, M; Delprat, B; Maurice, T; Laghezza, A; Abate, C Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (? Eur J Med Chem 228:0 (2022) [PubMed]  Article
Target
Name:
Sigma intracellular receptor 2
Synonyms:
S2r | SGMR2_RAT | Sigma intracellular receptor 2 | Sigma-2 receptor | Sigma2 receptor | Tmem97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20953.88
Organism:
Rattus norvegicus (Rat)
Description:
Q5U3Y7
Residue:
176
Sequence:
MGAVTARRCVEWLLGLYFVSHIPITMFIDLQALLPPELYPQEFSNLLRWYSKEFKDPLMQEPPVWFKSFLFCELVFQLPFFPIAAYAFFKGSCRWIRIPAIIYAVHTITTLIPILYTILFEDFSKAIAFKGQRPENFRERLTLVGVYAPYLIIPLILLLFMLRNPYYKFEEKRKKK
  
Inhibitor
Name:
BDBM50128108
Synonyms:
1-[2-(4-Chloro-phenoxy)-1-methyl-ethyl]-4-methyl-piperidine; hydrochloride | CHEMBL542873
Type:
Small organic molecule
Emp. Form.:
C15H22ClNO
Mol. Mass.:
267.794
SMILES:
C[C@H](COc1ccc(Cl)cc1)N1CCC(C)CC1
Structure:
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