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Target
Aurora kinase B
Ligand
BDBM50585516
Substrate
n/a
Meas. Tech.
ChEMBL_2162564 (CHEMBL5047425)
IC50
2512±n/a nM
Citation
 Wellaway, CR; Baldwin, IR; Bamborough, P; Barker, D; Bartholomew, MA; Chung, CW; Dümpelfeld, B; Evans, JP; Fazakerley, NJ; Homes, P; Keeling, SP; Lewell, XQ; McNab, FW; Morley, J; Needham, D; Neu, M; van Oosterhout, AJM; Pal, A; Reinhard, FBM; Rianjongdee, F; Robertson, CM; Rowland, P; Shah, RR; Sherriff, EB; Sloan, LA; Teague, S; Thomas, DA; Wellaway, N; Wojno-Picon, J; Woolven, JM; Coe, DM Investigation of Janus Kinase (JAK) Inhibitors for Lung Delivery and the Importance of Aldehyde Oxidase Metabolism. J Med Chem 65:633-664 (2022) [PubMed]  Article
Target
Name:
Aurora kinase B
Synonyms:
AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B
Type:
Protein
Mol. Mass.:
39327.72
Organism:
Homo sapiens (Human)
Description:
Q96GD4
Residue:
344
Sequence:
MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMENSSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEHQLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATIMEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYLPPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGAQDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
  
Inhibitor
Name:
BDBM50585516
Synonyms:
CHEMBL5075673
Type:
Small organic molecule
Emp. Form.:
C23H26FN5O
Mol. Mass.:
407.4838
SMILES:
[H][C@]12CC[C@]([H])(C[C@H](C1)Nc1cc(cc3cnc(N)nc13)-c1cc(F)c(O)cc1CC)N2 |r|
Structure:
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