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Target
Histone deacetylase 1
Ligand
BDBM50585748
Substrate
n/a
Meas. Tech.
ChEMBL_2163764 (CHEMBL5048625)
IC50
8700±n/a nM
Citation
 Belayet, JB; Beamish, S; Rahaman, M; Alanani, S; Virdi, RS; Frick, DN; Rahman, AFMT; Ulicki, JS; Biswas, S; Arnold, LA; Roni, MSR; Cheng, EY; Steeber, DA; Frick, KM; Hossain, MM Development of a Novel, Small-Molecule Brain-Penetrant Histone Deacetylase Inhibitor That Enhances Spatial Memory Formation in Mice. J Med Chem 65:3388-3403 (2022) [PubMed]  Article
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50585748
Synonyms:
CHEMBL5086240
Type:
Small organic molecule
Emp. Form.:
C22H38O6S2
Mol. Mass.:
462.664
SMILES:
CC(C)(C)OC(=O)CC(O)\C=C\CCSSCC\C=C\C(O)CC(=O)OC(C)(C)C
Structure:
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