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Target
Geranylgeranyl transferase type-2 subunit alpha
Ligand
BDBM50391242
Substrate
n/a
Meas. Tech.
ChEMBL_2264090
IC50
1400±n/a nM
Citation
 Gendaszewska-Darmach, E; Garstka, MA; B?a?ewska, KM Targeting Small GTPases and Their Prenylation in Diabetes Mellitus. J Med Chem 64:9677-9710 (2021) [PubMed]  Article
Target
Name:
Geranylgeranyl transferase type-2 subunit alpha
Synonyms:
2.5.1.60 | Geranylgeranyl transferase type II subunit alpha | Geranylgeranyl transferase type-2 subunit alpha | Ggta | PGTA_RAT | Rab GG transferase alpha | Rab GGTase alpha | Rab geranyl-geranyltransferase subunit alpha | Rab geranylgeranyltransferase subunit alpha | Rabggta
Type:
PROTEIN
Mol. Mass.:
64893.04
Organism:
Rattus norvegicus
Description:
ChEMBL_119712
Residue:
567
Sequence:
MHGRLKVKTSEEQAEAKRLEREQKLKLYQSATQAVFQKRQAGELDESVLELTSQILGANPDFATLWNCRREVLQHLETEKSPEESAALVKAELGFLESCLRVNPKSYGTWHHRCWLLSRLPEPNWARELELCARFLEADERNFHCWDYRRFVAAQAAVAPAEELAFTDSLITRNFSNYSSWHYRSCLLPQLHPQPDSGPQGRLPENVLLKELELVQNAFFTDPNDQSAWFYHRWLLGRAEPHDVLCCVHVSREEACLSVCFSRPLTVGSRMGTLLLMVDEAPLSVEWRTPDGRNRPSHVWLCDLPAASLNDQLPQHTFRVIWTGSDSQKECVLLKDRPECWCRDSATDEQLFRCELSVEKSTVLQSELESCKELQELEPENKWCLLTIILLMRALDPLLYEKETLQYFSTLKAVDPMRAAYLDDLRSKFLLENSVLKMEYADVRVLHLAHKDLTVLCHLEQLLLVTHLDLSHNRLRALPPALAALRCLEVLQASDNALENVDGVANLPRLQELLLCNNRLQQSAAIQPLVSCPRLVLLNLQGNSLCQEEGIQERLAEMLPSVSSILT
  
Inhibitor
Name:
BDBM50391242
Synonyms:
CHEMBL5276821
Type:
Small organic molecule
Emp. Form.:
C17H12O8
Mol. Mass.:
344.2724
SMILES:
COc1cc(C(O)=O)c2Oc3c(C=O)c(O)ccc3C(=O)Oc2c1C
Structure:
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