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Target
Kallikrein-1
Ligand
BDBM50157097
Substrate
n/a
Meas. Tech.
ChEMBL_302558 (CHEMBL839521)
Ki
336±n/a nM
Citation
 Bruncko, M; McClellan, WJ; Wendt, MD; Sauer, DR; Geyer, A; Dalton, CR; Kaminski, MA; Weitzberg, M; Gong, J; Dellaria, JF; Mantei, R; Zhao, X; Nienaber, VL; Stewart, K; Klinghofer, V; Bouska, J; Rockway, TW; Giranda, VL Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties. Bioorg Med Chem Lett 15:93-8 (2004) [PubMed]  Article
Target
Name:
Kallikrein-1
Synonyms:
KLK1 | KLK1_HUMAN | Kallikrein 1 | Kallikrein-1 | Kidney/pancreas/salivary gland kallikrein | Tissue kallikrein
Type:
Enzyme
Mol. Mass.:
28874.69
Organism:
Homo sapiens (Human)
Description:
P06870
Residue:
262
Sequence:
MWFLVLCLALSLGGTGAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAHCISDNYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHDLMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDECKKAHVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRVLSYVKWIEDTIAENS
  
Inhibitor
Name:
BDBM50157097
Synonyms:
6-[2-(1-Phenyl-3,4-dihydro-isoquinolin-7-yl)-cyclopropyl]-naphthalene-2-carboxamidine | CHEMBL182460
Type:
Small organic molecule
Emp. Form.:
C29H25N3
Mol. Mass.:
415.5289
SMILES:
NC(=N)c1ccc2cc(ccc2c1)C1CC1c1ccc2CCN=C(c3ccccc3)c2c1 |t:25|
Structure:
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