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Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50158226
Substrate
n/a
Meas. Tech.
ChEMBL_312673 (CHEMBL834820)
IC50
21±n/a nM
Citation
 Bao, J; Miao, S; Kayser, F; Kotliar, AJ; Baker, RK; Doss, GA; Felix, JP; Bugianesi, RM; Slaughter, RS; Kaczorowski, GJ; Garcia, ML; Ha, SN; Castonguay, L; Koo, GC; Shah, K; Springer, MS; Staruch, MJ; Parsons, WH; Rupprecht, KM Potent Kv1.3 inhibitors from correolide-modification of the C18 position. Bioorg Med Chem Lett 15:447-51 (2004) [PubMed]  Article
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50158226
Synonyms:
Aceticacid(R)-1-[(4R,4aR,5S,6R,6aR,11bS)-4,5,6-triacetoxy--hydroxy-2,4a,11b-trimethyl-1-(4-methyl-pent-3-enyl)-1,2,3,4,4a,4b,5,6,9,11a,11b,12,13,13a-tetradecahydro-8-oxa-cyclohepta[a]phenanthren-6a-yl]-ethyl ester | CHEMBL368429
Type:
Small organic molecule
Emp. Form.:
C37H54O10
Mol. Mass.:
658.8187
SMILES:
[#6]-[#6@@H](-[#8]-[#6](-[#6])=O)[C@]12[#6]-[#8]-[#6]-[#6]=[#6]-[#6]1[C@]1([#6])[#6]-[#6]-[#6]3C([#8])([#6]-[#6]\[#6]=[#6](\[#6])-[#6])[#6](-[#6])=[#6]-[#6@@H](-[#8]-[#6](-[#6])=O)[C@]3([#6])[#6]1-[#6@H](-[#8]-[#6](-[#6])=O)-[#6@@H]2-[#8]-[#6](-[#6])=O |c:10,28|
Structure:
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