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Target
Potassium voltage-gated channel subfamily A member 3
Ligand
BDBM50158230
Substrate
n/a
Meas. Tech.
ChEMBL_312032 (CHEMBL834727)
IC50
35±n/a nM
Citation
 Bao, J; Miao, S; Kayser, F; Kotliar, AJ; Baker, RK; Doss, GA; Felix, JP; Bugianesi, RM; Slaughter, RS; Kaczorowski, GJ; Garcia, ML; Ha, SN; Castonguay, L; Koo, GC; Shah, K; Springer, MS; Staruch, MJ; Parsons, WH; Rupprecht, KM Potent Kv1.3 inhibitors from correolide-modification of the C18 position. Bioorg Med Chem Lett 15:447-51 (2004) [PubMed]  Article
Target
Name:
Potassium voltage-gated channel subfamily A member 3
Synonyms:
HGK5 | HLK3 | HPCN3 | HuKIII | KCNA3 | KCNA3_HUMAN | Potassium voltage-gated channel subfamily A member 3 | Voltage-gated potassium channel | Voltage-gated potassium channel subunit Kv1.3
Type:
PROTEIN
Mol. Mass.:
63835.47
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1513935
Residue:
575
Sequence:
MDERLSLLRSPPPPSARHRAHPPQRPASSGGAHTLVNHGYAEPAAGRELPPDMTVVPGDHLLEPEVADGGGAPPQGGCGGGGCDRYEPLPPSLPAAGEQDCCGERVVINISGLRFETQLKTLCQFPETLLGDPKRRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRIRRPVNVPIDIFSEEIRFYQLGEEAMEKFREDEGFLREEERPLPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCLETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVRFFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADDPTSGFSSIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQSQYMHVGSCQHLSSSAEELRKARSNSTLSKSEYMVIEEGGMNHSAFPQTPFKTGNSTATCTTNNNPNSCVNIKKIFTDV
  
Inhibitor
Name:
BDBM50158230
Synonyms:
CHEMBL362199 | Correloid derivative
Type:
Small organic molecule
Emp. Form.:
C39H52O16
Mol. Mass.:
776.8206
SMILES:
COC(=O)C12O[C@@H]1C(=O)CC1(O)C3CC[C@@]4(C)C5C=CCOC[C@]5([C@@H](C)OC(C)=O)[C@@H](OC(C)=O)[C@@H](OC(C)=O)C4[C@@]3(C)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@@]21C |c:19|
Structure:
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