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Target
Glutamate receptor 4
Ligand
BDBM50158556
Substrate
n/a
Meas. Tech.
ChEMBL_430654 (CHEMBL919619)
IC50
>100000±n/a nM
Citation
 Valgeirsson, J; Nielsen, EO; Peters, D; Mathiesen, C; Kristensen, AS; Madsen, U Bioisosteric modifications of 2-arylureidobenzoic acids: selective noncompetitive antagonists for the homomeric kainate receptor subtype GluR5. J Med Chem 47:6948-57 (2004) [PubMed]  Article
Target
Name:
Glutamate receptor 4
Synonyms:
GRIA4_RAT | Glur4 | Glutamate receptor ionotropic, AMPA 4 | Glutamate receptors NMDA/AMPA | Gria4
Type:
PROTEIN
Mol. Mass.:
100766.57
Organism:
Rattus norvegicus
Description:
ChEMBL_539474
Residue:
902
Sequence:
MRIICRQIVLLFSGFWGLAMGAFPSSVQIGGLFIRNTDQEYTAFRLAIFLHNTSPNASEAPFNLVPHVDNIETANSFAVTNAFCSQYSRGVFAIFGLYDKRSVHTLTSFCSALHISLITPSFPTEGESQFVLQLRPSLRGALLSLLDHYEWNCFVFLYDTDRGYSILQAIMEKAGQNGWHVSAICVENFNDVSYRQLLEELDRRQEKKFVIDCEIERLQNILEQIVSVGKHVKGYHYIIANLGFKDISLERFIHGGANVTGFQLVDFNTPMVTKLMDRWKKLDQREYPGSETPPKYTSALTYDGVLVMAETFRSLRRQKIDISRRGNAGDCLANPAAPWGQGIDMERTLKQVRIQGLTGNVQFDHYGRRVNYTMDVFELKSTGPRKVGYWNDMDKLVLIQDMPTLGNDTAAIENRTVVVTTIMESPYVMYKKNHEMFEGNDKYEGYCVDLASEIAKHIGIKYKIAIVPDGKYGARDADTKIWNGMVGELVYGKAEIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEPEDGKEGPSDQPPNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLDSGSTKEFFRRSKIAVYEKMWTYMRSAEPSVFTRTTAEGVARVRKSKGKFAFLLESTMNEYTEQRKPCDTMKVGGNLDSKGYGVATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKDKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKLTFSEATRNKARLSITGSVGENGRVLTPDCPKAVHTGTAIRQSSGLAVIASDLP
  
Inhibitor
Name:
BDBM50158556
Synonyms:
1-(3-bromophenyl)-3-[5-chloro-2-(1H-tetrazol-5-yl-phenyl]urea | CHEMBL224926
Type:
Small organic molecule
Emp. Form.:
C14H10BrClN6O
Mol. Mass.:
393.626
SMILES:
Clc1ccc(-c2nnn[nH]2)c(NC(=O)Nc2cccc(Br)c2)c1
Structure:
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