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Target
Histamine H2 receptor
Ligand
BDBM50159114
Substrate
n/a
Meas. Tech.
ChEMBL_306186 (CHEMBL830980)
IC50
>10000±n/a nM
Citation
 Zaragoza, F; Stephensen, H; Peschke, B; Rimvall, K 2-(4-alkylpiperazin-1-yl)quinolines as a new class of imidazole-free histamine H3 receptor antagonists. J Med Chem 48:306-11 (2005) [PubMed]  Article
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50159114
Synonyms:
CHEMBL179234 | Cyclopropyl-[2-(4-cyclopropyl-piperazin-1-yl)-quinolin-6-yl]-methanone
Type:
Small organic molecule
Emp. Form.:
C20H23N3O
Mol. Mass.:
321.4161
SMILES:
O=C(C1CC1)c1ccc2nc(ccc2c1)N1CCN(CC1)C1CC1
Structure:
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