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Target
D(4) dopamine receptor
Ligand
BDBM50263488
Substrate
n/a
Meas. Tech.
ChEMBL_2194224 (CHEMBL5106584)
Ki
2.9±n/a nM
Citation
 Pavleti?, P; Semeano, A; Yano, H; Bonifazi, A; Giorgioni, G; Piergentili, A; Quaglia, W; Sabbieti, MG; Agas, D; Santoni, G; Pallini, R; Ricci-Vitiani, L; Sabato, E; Vistoli, G; Del Bello, F Highly Potent and Selective Dopamine D J Med Chem 65:12124-12139 (2022) [PubMed]  Article
Target
Name:
D(4) dopamine receptor
Synonyms:
D(2C) dopamine receptor | DOPAMINE D4 | DOPAMINE D4.2 | DOPAMINE D4.4 | DRD4 | DRD4_HUMAN | Dopamine D4 receptor
Type:
Enzyme
Mol. Mass.:
48373.19
Organism:
Homo sapiens (Human)
Description:
P21917
Residue:
419
Sequence:
MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPSLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
  
Inhibitor
Name:
BDBM50263488
Synonyms:
CHEMBL4085780
Type:
Small organic molecule
Emp. Form.:
C22H27N3O
Mol. Mass.:
349.4693
SMILES:
O=C1CCc2ccccc2N1CCCN1CCN(CC1)c1ccccc1
Structure:
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