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Target
Stromelysin-1
Ligand
BDBM50589979
Substrate
n/a
Meas. Tech.
ChEMBL_2194631 (CHEMBL5106991)
IC50
33000±n/a nM
Citation
 Alhayek, A; Abdelsamie, AS; Schönauer, E; Camberlein, V; Hutterer, E; Posselt, G; Serwanja, J; Blöchl, C; Huber, CG; Haupenthal, J; Brandstetter, H; Wessler, S; Hirsch, AKH Discovery and Characterization of Synthesized and FDA-Approved Inhibitors of Clostridial and Bacillary Collagenases. J Med Chem 65:12933-12955 (2022) [PubMed]  Article
Target
Name:
Stromelysin-1
Synonyms:
MMP-3 | MMP3 | MMP3_HUMAN | Matrix metalloproteinase (2 and 3) | Matrix metalloproteinase 3 | Matrix metalloproteinase-3 | Matrix metalloproteinase-3 (MMP-3) | Matrix metalloproteinase-3 (MMP3) | SL-1 | STMY1 | Stromelysin 1 | Transin-1
Type:
Enzyme
Mol. Mass.:
53973.13
Organism:
Homo sapiens (Human)
Description:
P08254
Residue:
477
Sequence:
MKSLPILLLLCVAVCSAYPLDGAARGEDTSMNLVQKYLENYYDLKKDVKQFVRRKDSGPVVKKIREMQKFLGLEVTGKLDSDTLEVMRKPRCGVPDVGHFRTFPGIPKWRKTHLTYRIVNYTPDLPKDAVDSAVEKALKVWEEVTPLTFSRLYEGEADIMISFAVREHGDFYPFDGPGNVLAHAYAPGPGINGDAHFDDDEQWTKDTTGTNLFLVAAHEIGHSLGLFHSANTEALMYPLYHSLTDLTRFRLSQDDINGIQSLYGPPPDSPETPLVPTEPVPPEPGTPANCDPALSFDAVSTLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGFPPTVRKIDAAISDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEFDPNAKKVTHTLKSNSWLNC
  
Inhibitor
Name:
BDBM50589979
Synonyms:
CHEMBL5177477
Type:
Small organic molecule
Emp. Form.:
C8H6Cl2N2O6P2
Mol. Mass.:
358.997
SMILES:
OP(O)(=O)c1nc2cc(Cl)c(Cl)cc2nc1P(O)(O)=O
Structure:
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