Reaction Details Report a problem with these data
Target
Melanocortin receptor 5
Ligand
BDBM50590025
Substrate
n/a
Meas. Tech.
ChEMBL_2194702 (CHEMBL5107062)
IC50
15136±n/a nM
Citation
White, AM; Dellsén, A; Larsson, N; Kaas, Q; Jansen, F; Plowright, AT; Knerr, L; Durek, T; Craik, DJ Late-Stage Functionalization with Cysteine Staples Generates Potent and Selective Melanocortin Receptor-1 Agonists. J Med Chem 65:12956-12969 (2022) [PubMed] Article
More Info.:
Target
Name:
Melanocortin receptor 5
Synonyms:
MC-2 | MC5-R | MC5R | MC5R_HUMAN | Melanocortin MC5 | Melanocortin receptor (M4 and M5) | Melanocortin receptor 5 | Melanocortin receptor 5 (MC5R)
Type:
Enzyme
Mol. Mass.:
36612.92
Organism:
Homo sapiens (Human)
Description:
P33032
Residue:
325
Sequence:
MNSSFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVKNKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMICISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAFCTGCGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGASSARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMCNSVMDPLIYAFRSQEMRKTFKEIICCRGFRIACSFPRRD
Inhibitor
Name:
BDBM50590025
Synonyms:
CHEMBL5195937
Type:
Small organic molecule
Emp. Form.:
C66H90N16O11S2
Mol. Mass.:
1347.651
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](Cc1c[nH]c3ccccc13)NC(=O)[C@H](CCCNC(N)=N)N(C)C(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@@]([H])(NC(=O)[C@@H](CCSCc1ccccc1CSCC[C@@H](NC(=O)[C@@]([H])(NC2=O)[C@@H](C)CC)C(N)=O)NC(C)=O)[C@@H](C)O |r|