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Target
BDNF/NT-3 growth factors receptor
Ligand
BDBM50513229
Substrate
n/a
Meas. Tech.
ChEMBL_2196852 (CHEMBL5109368)
IC50
685±n/a nM
Citation
 Wang, Z; Ren, J; Jia, K; Zhao, Y; Liang, L; Cheng, Z; Huang, F; Zhao, X; Cheng, J; Song, S; Sheng, T; Wan, W; Shu, Q; Wu, D; Zhang, J; Lu, T; Chen, Y; Ran, T; Lu, S Identification and structural analysis of a selective tropomyosin receptor kinase C (TRKC) inhibitor. Eur J Med Chem 241:0 (2022) [PubMed]  Article
Target
Name:
BDNF/NT-3 growth factors receptor
Synonyms:
GP145-TrkB | NTRK1/NTRK2 | NTRK2 | NTRK2_HUMAN | Neurotrophic tyrosine kinase receptor type 2 | TRKB | Trk-B | TrkB tyrosine kinase | Tropomyosin-related kinase B | Tropomyosin-related kinase B (TRKB) | Tyrosine kinase receptor B (Trk-B)
Type:
Enzyme
Mol. Mass.:
91996.87
Organism:
Homo sapiens (Human)
Description:
Q16620
Residue:
822
Sequence:
MSSWIRWHGPAMARLWGFCWLVVGFWRAAFACPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHMRKNIKGIHTLLQNLAKASPVYLDILG
  
Inhibitor
Name:
BDBM50513229
Synonyms:
CHEMBL4470728
Type:
Small organic molecule
Emp. Form.:
C24H27N5O3
Mol. Mass.:
433.5029
SMILES:
CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1cc(n[nH]1)-c1ccc2OCCOc2c1
Structure:
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