Reaction Details  Report a problem with these data
Target
NT-3 growth factor receptor
Ligand
BDBM50513246
Substrate
n/a
Meas. Tech.
ChEMBL_2196853 (CHEMBL5109369)
IC50
42±n/a nM
Citation
 Wang, Z; Ren, J; Jia, K; Zhao, Y; Liang, L; Cheng, Z; Huang, F; Zhao, X; Cheng, J; Song, S; Sheng, T; Wan, W; Shu, Q; Wu, D; Zhang, J; Lu, T; Chen, Y; Ran, T; Lu, S Identification and structural analysis of a selective tropomyosin receptor kinase C (TRKC) inhibitor. Eur J Med Chem 241:0 (2022) [PubMed]  Article
Target
Name:
NT-3 growth factor receptor
Synonyms:
GP145-TrkC | NTRK3 | NTRK3_HUMAN | Neurotrophic tyrosine kinase receptor | Neurotrophic tyrosine kinase receptor type 3 | TRKC | Trk-C | TrkC tyrosine kinase | Tyrosine kinase receptor C (Trk-C)
Type:
Enzyme
Mol. Mass.:
94428.15
Organism:
Homo sapiens (Human)
Description:
Q16288
Residue:
839
Sequence:
MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEAKLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISEGCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
  
Inhibitor
Name:
BDBM50513246
Synonyms:
CHEMBL4473123
Type:
Small organic molecule
Emp. Form.:
C24H27N5O2
Mol. Mass.:
417.5035
SMILES:
CN1CCC(CC1)Nc1ccc(cc1)C(=O)Nc1cc(n[nH]1)-c1ccc2OCCc2c1
Structure:
Search PDB for entries with ligand similarity: