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Target
Sodium-dependent phosphate transport protein 2B
Ligand
BDBM50590497
Substrate
n/a
Meas. Tech.
ChEMBL_2196957 (CHEMBL5109473)
IC50
15±n/a nM
Citation
 Maemoto, M; Hirata, Y; Hosoe, S; Ouchi, J; Uchii, M; Takada, H; Akizawa, E; Yanagisawa, A; Shuto, S Development of potent non-acylhydrazone inhibitors of intestinal sodium-dependent phosphate transport protein 2b (NaPi2b). Bioorg Med Chem 71:0 (2022) [PubMed]  Article
Target
Name:
Sodium-dependent phosphate transport protein 2B
Synonyms:
NPT2B_HUMAN | Na(+)-dependent phosphate cotransporter 2B | Na(+)/Pi cotransporter 2B | NaPi-2b | NaPi3b | SLC34A2 | Sodium-phosphate transport protein 2B | Sodium/phosphate cotransporter 2B | Solute carrier family 34 member 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
75771.66
Organism:
Homo sapiens (Human)
Description:
O95436
Residue:
690
Sequence:
MAPWPELGDAQPNPDKYLEGAAGQQPTAPDKSKETNKTDNTEAPVTKIELLPSYSTATLIDEPTEVDDPWNLPTLQDSGIKWSERDTKGKILCFFQGIGRLILLLGFLYFFVCSLDILSSAFQLVGGKMAGQFFSNSSIMSNPLLGLVIGVLVTVLVQSSSTSTSIVVSMVSSSLLTVRAAIPIIMGANIGTSITNTIVALMQVGDRSEFRRAFAGATVHDFFNWLSVLVLLPVEVATHYLEIITQLIVESFHFKNGEDAPDLLKVITKPFTKLIVQLDKKVISQIAMNDEKAKNKSLVKIWCKTFTNKTQINVTVPSTANCTSPSLCWTDGIQNWTMKNVTYKENIAKCQHIFVNFHLPDLAVGTILLILSLLVLCGCLIMIVKILGSVLKGQVATVIKKTINTDFPFPFAWLTGYLAILVGAGMTFIVQSSSVFTSALTPLIGIGVITIERAYPLTLGSNIGTTTTAILAALASPGNALRSSLQIALCHFFFNISGILLWYPIPFTRLPIRMAKGLGNISAKYRWFAVFYLIIFFFLIPLTVFGLSLAGWRVLVGVGVPVVFIIILVLCLRLLQSRCPRVLPKKLQNWNFLPLWMRSLKPWDAVVSKFTGCFQMRCCCCCRVCCRACCLLCDCPKCCRCSKCCEDLEEAQEGQDVPVKAPETFDNITISREAQGEVPASDSKTECTAL
  
Inhibitor
Name:
BDBM50590497
Synonyms:
CHEMBL5182987
Type:
Small organic molecule
Emp. Form.:
C49H64ClF3N6O8S
Mol. Mass.:
989.581
SMILES:
CCC(CC)N(CCN(C)C(=O)CCC(=O)NCCOCCOCCOCCO)Cc1cccc(c1)C(=O)Nc1sc2CC(C)(C)CCc2c1C(=O)c1cnn(c1)-c1ccc(Cl)c(c1)C(F)(F)F
Structure:
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